Preparation and Characterization of Dexamethasone Microemulsion Based on Pseudoternary Phase Diagram

Preparation and Characterization of Dexamethasone Microemulsion Based on Pseudoternary Phase Diagram

BACKGROUND The increased incidence of inflammatory diseases has necessitated the need to search for new topical dosage form of dexamethasone. OBJECTIVES The purpose of the present study was the preparation and evaluation of novel microemulsion as a topical delivery system for dexamethasone by mixing appropriate amount of surfactant including Tween 80 and Labrasol, cosurfactant such as capryol...

preparation and characterization of dexamethasone microemulsion based on pseudoternary phase diagram

results the results showed that the maximum oil was incorporated in microemulsion system that contained surfactant to cosurfactant ratio of 4:1. the mean droplet size range of microemulsion formulation was in the range of 5.09 to 159 nm, and its refractory index (ri) and ph were 1.44 and 7, respectively. viscosity range was 57-226 cps. drug release profile showed that 48.18% of the drug release...

preparation and evaluation of tretinoin microemulsion based on pseudo-ternary phase diagram

formulation of diclofenac microemulsion based on phase diagram

Preparation and evaluation of tretinoin microemulsion based on pseudo-ternary phase diagram.

PURPOSE The aim of the present research was to formulate a transparent microemolsion as a topical delivery system for tretinoin for the treatment of acne. METHODS Microemulsion formulations prepared by mixing appropriate amount of surfactant including Tween 80 and Labrasol, co-surfactant such as propylene glycol (PG) and oil phase including isopropyl myristate - transcutol P (10:1 ratio). The...